Pyroptosis of NKT cells


   题目:  Pyroptosis of NKT cells.   


  报告人:  Li, Xian Chang MD. PhD.   

  Immunobiology & Transplant Science Center, Houston Methodist Hospital, Texas Medical Center   

  报告地点:中科院动物所D- 122   

  邀请人:  赵勇 研究员   

  Personal Statement:

  Li, Xian Chang MD. PhD. has long-standing interests in transplant immunology, especially in the mechanisms and applications of immune tolerance. For over twenty years, his research focus has been on T cell fate decisions and innate immune cells, and how those events and cells affect transplant outcomes. He has published extensively in areas of transplantation and immunology, including papers in high impact journals, and some of the papers have become cornerstones in transplant research. He is recognized with multiple awards and elected memberships, and has played leadership roles in professional societies, NIH study sections, ITN and DOD review panels, as well as in institutional committees, chaired and organized numerous scientific sessions in national and international meetings. He has served or still serving as an editorial board member for leading scientific journals including J Immunol, Am J Transplant, Transplantation. Thus, He believes he has the expertise and leadership skills to accomplish the proposed studies.    

  Representative Publications: 

  1. Li XC, Strom TB, Turka LA, Wells AD. T cell death and transplantation tolerance. Immunity 2001; 14: 407-416 PMCID11336686

  2. Li XC, Rothstein DM, Sayegh MH. Costimulatory pathways in transplantation: challenges and new developments. Immunological Reviews 2009; 229: 271-293 PMCID19426228

  3. Cobbold SP and Li XC. Editors. Translating tolerogenic therapies to the clinic- where do we stand and what are the barriers? Frontiers in Immunology October 2012 (ebook, 234 pages)

  4. Li XC and Jevnikar AM. Editors. AST Transplant Immunology, Willey Blackwell Production 2015(textbook, 348 pages)  

  5. Vu MD, Xiao X, Gao W, Degauque N, Chen M, Kroemer A, Killeen N, Ishii N, Li XC. OX40 costimulation turns off Foxp3+ Tregs. Blood 2007; 110: 2501-2510 PMCID17575071 (Featured

  in Inside Blood-OX40 and regulatory T cells; Faculty 1000 Immunology)

  6. Xiao X, Balasubramanian S, Liu W, Chu X, Wang W, Taparowsky EJ, Fu YX, Choi Y, Walsh MC,

  Li XC. OX40 signaling favors the induction of Th9 cells and airway inflammation.

  Nature Immunology 2012; 13: 981-990 PMCID22842344 (Featured in News and Views- Yoking OX40 to regulation of IL-9; Science Daily July 29, 2012- Cell receptor has proclivity to Th9 cells and airway inflammation; Medical News Digest Aug 1, 2012- Research findings may affect how doctors treat allergic inflammation and chronic rejection)

  7. Xiao X, Shi X, Fan Y, Zhang X, Wu M, Lan P, Minze L, Fu YX, Ghobrial RM, Liu W, Li XC. GITR

  subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation. Nature Communications 2015; 6: 8266 doi 10.1038/ncomms9266 PMCID4570275 (Featured in Science Daily Sept 14, 2015- Study shows protein creates cancer fighting cells)

  8. Xiao X, Shi X, Fan Y, Wu C, Zhang X, Minze L, Liu W, Ghobrial RM, Lan P, Li XC. The costimulatory receptor OX40 inhibits IL-17 expression through activation of repressive chromatin remodeling pathways. Immunity 2016; 44: 12-71-1283 PMCID27317259