Epigenetic inheritance and reprogramming across the generation
题目：Epigenetic inheritance and reprogramming across the generation
Time: 10 am, Dec 28 2016 (Wednesday),
Venue: C101, IOZ
Inviter: Dr. Feng Liu, 010-64807307
Fertilization marks the beginning of a new life. This is followed by drastic epigenetic reprogramming that converts terminally differentiated oocyte and sperm to totipotent embryos. However, how chromatin is reprogrammed at the DNA level in early development is poorly understood. Furthermore, whether histone modifications, the crucial epigenetic regulators, can be passed on from parents to the next generation is a long-standing question that remains elusive. By developing cutting-edge technologies, we recently investigated dynamic regulation of chromatin and histone modifications from gametes to the next generation in mice. In addition, we also showed how parental memory is controlled by a simple isoform switch of an epigenetic regulator. Our studies not only revealed extremely dynamic, non-canonical epigenomic reprogramming that accompanies early embryogenesis, but also shed lights on the fundamental principles underlying epigenetic inheritance between generations.